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The Application Of Centrifuges In The Medical Industry Is Mainly Based On Blood Tests.

Oct 27, 2015

People's health can not be ignored, but if there is a problem with the blood, people will get sick. Therefore, in the hospital, blood tests are routine inspection items, and the accuracy of blood garbage detection is 99%. These include cholesterol crystals, thrombus bands, lipid plaques, intestinal black poisons, chylomicrons, microbes, bacteria or viruses, and parasites. Most of these garbage will not change with the increase of temperature and exercise volume, and will not disappear by itself as long as the patient exists.

How does the centrifuge separate the blood sample:

First, after the doctor takes the blood collection tube, it will be placed on the vacuum blood collection tube shelf. When a certain amount is reached, it will be placed in a centrifuge for centrifugation.

The number of centrifugations must be even, because one tube can't be centrifuged. The centrifuge needs to be balanced during the centrifugation process. Although some centrifuges are automatically balanced, it is impossible to say that one tube can be centrifuged, but it is relatively The difference is not a large weight to maintain normal operating conditions.

In the pharmaceutical industry, due to stricter requirements on production quality and production safety, the main process equipment for the production process of raw materials in centrifuges and other pharmaceutical production fields also has extremely high requirements. In addition to maintaining its own separation characteristics, centrifuges also need to meet the relevant specifications and standards in the medical field. Medicinal centrifuges need to consider materials, structures, material input and output methods, safety, labor intensity, control, cleaning or disinfection and sterilization from the perspective of meeting the requirements of the pharmaceutical production process.

Centrifuges have a very high force during centrifugation, which can lead to accidents if unbalanced.

Therefore, when the doctor puts the test tube into the centrifuge, it is symmetrical. After the centrifuge is started, the speed of the rotation is slowly increased, and then the set speed is reached. When the set time is reached, the centrifugal machine automatically stops. Due to the inertia, the speed of the centrifuge will slowly drop from the set speed and will not stop immediately to zero.

The medicinal centrifuge has the requirements of cleaning and sterilizing when changing batches and changing varieties in production, preventing various pollution sources and avoiding re-contamination. The medicinal centrifuge needs to work hard in the aspects of automatic program control, human-machine isolation operation, easy cleaning, sterilizable and sterilizable structure, on-line analysis and separation and separation of different trait materials, improving function, control and sterilizing operation. Level.

Since the centrifuge in the medical field should be released from the drug, the surface of the centrifuge device must be smooth, flat, and free of dead angles. Therefore, it is necessary to ensure that the sharp corners, corners, and welds of the centrifuge are ground into a smooth transition circle during the manufacturing process. angle. Because of the need to make contact with the drug, the centrifuge needs to be resistant to corrosion, chemical changes or drug adsorption.

After the centrifuge is stopped, the door cover cannot be opened immediately. It needs to wait until the speed of the centrifuge will be zero. The medical centrifuge will highlight the current speed on the screen.

When the speed is zero, the door will open automatically. At this time, the doctor will take out the centrifuged blood collection tube, put it on the test tube rack, and then send it to check the centrifugation time and relative centrifugal force (RCF): clinical chemical analysis when the blood sample is centrifuged. , RCF (1000 ~ 1200) × g, centrifugation time is 5 ~ 10 min.

Temperature Control Centrifugation: Heat production during centrifugation is not conducive to analyte stability. Clinical chemical analysis Blood samples must be centrifuged with a temperature controlled centrifuge. Some temperature-dependent analytes (such as adrenocorticotropic hormone, cyclic adenosine monophosphate, catecholamines, etc.) should be separated at 4 ° C;

For analytes without special temperature requirements, the centrifugation temperature should be set at 20 ° C ~ 22 ° C; the temperature below 15 ° C can artificially increase the blood potassium measurement; refrigerated transport specimens must be centrifuged at the required temperature.

About re-centrifugation: The centrifugation of the specimen is preferably done once. If it is necessary to centrifuge again, it should be separated from the last centrifugation for a short time; for blood samples containing the separated substance, it can never be centrifuged again.

With the development of centrifuges, the technology related to centrifuges has improved. However, the pharmaceutical industry cannot be safer than the status quo and must continue to develop. With the support of national policies, centrifuge enterprises must continuously strive to promote the wider application of centrifuges in the pharmaceutical industry.


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